Author

Ghazaleh Eskandari‐Sedighi

University of AlbertaORCID 0000-0003-0447-7722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alina L Chadarevian· 1 shared Alissa L. NanaiD· 1 shared Ani Agababian· 1 shared Bret Holt· 1 shared Chris D. St. LaurentiD· 1 shared Claire Dudley ClellandiD· 1 shared Eric Jinsheng HuangiD· 1 shared Erik Gomez· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alina L Chadarevian

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2 papers

Recent·Most cited

NeuroscienceMolecular NeurodegenerationPeer-reviewedJul 16, 2026

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Hayk Davtyan, Sarah A. Naguib, Yuliya Voskobiynyk…·Li Gan

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

2 citationstop 2%

mouseexperimental assay

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NeurosciencebioRxivPreprintJul 4, 2023

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia…·Matthew Scott Macauley

This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.

3 citations

mousescRNA-seq

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