Pharmacology & ToxicologybioRxivPreprint
N'-(1-phenylethylidene)-benzohydrazide cytotoxicity is LSD1 independent and linked to Fe-S cluster disruption in Ewing sarcoma
John William Sherman, Galen C. Rask, Bingcong Xiong…·Emily R. Theisen
This paper identifies that SP-2509 and SP-2577, LSD1 inhibitors, induce cell death in Ewing sarcoma through Fe-S cluster disruption, independent of LSD1 inhibition.
DOI 10.1101/2025.06.20.660795