Eranthie Weerapana

A MultiOmics time-resolved systems map of gene regulation in Toxoplasma gondii

This study creates a time-resolved multi-omics map of gene regulation in Toxoplasma gondii by integrating perturbation data with single-cell measurements, revealing regulatory networks and novel interactions.

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds anFe-S Cluster

This study identifies Fe-S cluster ligands in HBx, showing it binds both Fe-S and Zn, with implications for HBV replication and drug targeting.

A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress

This study identifies a nitrite-responsive regulatory RNA locus in Bacteroides thetaiotaomicron that enhances resilience to nitrosative stress during intestinal inflammation.

Discovery of a cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions

The paper identifies a [4Fe-4S] cluster in PRRSV Nsp1α leader protease, showing its role in modulating protease activity and host-virus interactions.

Rational engineering of facultative anaerobiosis enables commensal survival in the oxygenated gut

This study engineers obligate anaerobic bacteria to tolerate oxygen, improving their survival in the gut.

A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

Exploring metalloproteome remodeling in calprotectin-stressed Acinetobacter baumannii using chemoproteomics

This study uses chemoproteomics to show that calprotectin stress in Acinetobacter baumannii leads to undermetalation of metalloproteomes, impairing key metabolic and cellular processes.

Hydrogen sulfide increases intracellular oxygen and regulates the HIF response

This study shows hydrogen sulfide increases intracellular oxygen and destabilizes HIF-1, altering hypoxia sensing and potentially contributing to O2 toxicity diseases.

N'-(1-phenylethylidene)-benzohydrazide cytotoxicity is LSD1 independent and linked to Fe-S cluster disruption in Ewing sarcoma

This paper identifies that SP-2509 and SP-2577, LSD1 inhibitors, induce cell death in Ewing sarcoma through Fe-S cluster disruption, independent of LSD1 inhibition.

Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.

This paper identifies RACK1 as a redox-regulated hub that coordinates cellular stress responses through condensate-based microdomains, linking environmental stress to immune signaling and translational control.