Alexander Muik

This study evaluates the immunogenicity of an LP.8.1-adapted BNT162b2 vaccine against JN.1 sublineages, showing higher neutralizing antibody responses compared to other adapted vaccines.

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.

Omicron JN.1- and KP.2-adapted BNT162b2 mRNA vaccines elicit stronger neutralizing antibody responses against circulating sublineages than previous vaccines, supporting annual strain updates.

A COVID-19 Early Warning System combines structural modelling with machine learning to detect and monitor high risk SARS-CoV-2 variants, identifying all 16 WHO designated variants on average more than one and a half months in advance by selecting on average less than 0.3% of the weekly novel variants.