Author
Darpan Medhi
Memorial Sloan Kettering Cancer CenterORCID 0009-0008-1493-568XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2016-2026 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author links4 papers
Recent·Most cited
- Molecular BiologyMolecular CellPeer-reviewed
Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks
Samantha B. Regan, Darpan Medhi, Yuanlin Xu…·Maria Jasin
This study investigates LOH caused by CRISPR-Cas9 DSBs, showing large-scale loss and mechanisms, and highlights risks when combined with end joining inhibition.
24 citationstop 2% - GeneticsG3 Genes Genomes GeneticsPeer-reviewed
Noncanonical contributions of MutLγ to VDE-initiated crossovers during Saccharomyces cerevisiae meiosis
Anura Shodhan, Darpan Medhi, Michael Lichten
The paper shows that Mlh3 dependence of VDE-initiated crossovers varies with genomic location, and Pch2 influences this dependence across different loci.
4 citations - GeneticsbioRxiv
Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis
Darpan Medhi, Alastair S.H. Goldman, Michael Lichten
The paper shows that chromosome structure determines whether crossover recombination in budding yeast uses MutLγ or not, depending on Hop1 protein levels.
DOI 10.7554/elife.19669