Douglas G. Mashek

This paper develops a low-input prenylomic workflow to enable cell-type-specific analysis of prenylated proteins in mouse liver tissue.

This study identifies acetylated PLIN2 as a critical mediator of inflammation by facilitating oxylipin synthesis on lipid droplets through interactions with inflammatory proteins.

This study shows that ATGL-catalyzed lipid catabolism enhances DNA double-strand break repair, reducing genomic instability and aging-related damage.

The paper shows that ketone bodies support thermogenic adaptation in BAT during fasting by promoting lipid remodeling and thermogenesis.

This study shows sorbate induces lysine sorbylation via Class I HDACs, altering inflammation gene expression without affecting histone acetylation.