Samuel Eriksson Lidbrink

This study identifies molecular determinants of ligand recognition and efficacy in TRPM3's voltage sensor-like domain using a combination of structural and functional analyses.

The paper evaluates MSA perturbation methods on AlphaFold3 to improve sampling of alternative protein states, finding significant improvements in TM-scores compared to unperturbed AF3.

The paper identifies a single main-chain hydrogen bond in the β2 subunit M2-M3 linker that inhibits GABAA receptor pore opening and is required to keep the unliganded channel closed.

This paper combines AlphaFold with small-angle scattering data to predict multiple conformational states of a membrane protein under specific conditions and their transition pathways.

This study uses molecular dynamics simulations and Markov state modeling to predict an open state of GABAA receptors, showing chloride ion conductance and desensitization mechanisms.