Developing a Multimodal miR-15a Mimic to Overcome Gemcitabine and RAS(ON) Inhibitor Daraxonrasib Resistance in Pancreatic Ductal Adenocarcinoma
Amartya Pal, Anushka Ojha, John G Yuen…·Jingfang G Ju
This paper develops a multimodal miR-15a-based therapeutic that overcomes resistance to gemcitabine and daraxonrasib in PDAC by combining gene regulation and nucleotide metabolism disruption, showing potent antitumor effects in vitro and in vivo.