This paper constructs a CITE-seq-based atlas of mouse hematopoietic progenitors, identifying 28 progenitor stages across eight lineages and novel surface markers.

bioRxiv · Sep 12, 2026 · PreprintImmunology

CITE-seq of murine bone marrow plasmacytoid dendritic cells and haematopoietic progenitor cells in sepsis

Johannes Andreas Korfhage, Elena Siakaeva, Mahamudul Hasan Bhuyan, Bettina Budeus, Dimitris Ttoouli, Tobias Lautwein, Stefanie B. Flohé, Stefanie Scheu

The paper provides CITE-seq data of bone marrow cells from septic and sham mice to study transcriptional and surface marker changes in sepsis.

bioRxiv · Jul 21, 2026 · PreprintImmunology

Th17 cells require the DNA repair sensor XPC to control oxidative DNA damage

Jefferson Antônio Leite, Natalia Notarberardino Bos, Luísa Menezes-Silva, Eloísa Martins da Silva, Giovana da Silva Leandro, Guilherme Comparotto Moreira de Goes, Patrick da Silva, S. A. Oliveira, Eder Soares de Almeida Santos, Hedden Ranfley, Ilaria Palagi, Magaiver Andrade-Silva, Camila Pontes Ferreira, José Arimatéa de Oliveira Nery Neto, Victor Yuji Yariwake, , Niels Olsen Saraiva Câmara

This study identifies XPC as essential for protecting Th17 cells from oxidative DNA damage, showing its role in DNA repair, differentiation, and function.

Nature Communications · Apr 1, 2026Peer-reviewedImmunology

Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells

Julian Schliehe‐Diecks, Jia‐Wey Tu, Paweł Stachura, Katerina Schaal, Marie Kemkes, Eleni Vasileiou, Nadine Rüchel, Danielle Brandes, Melina Vogt, Thomas Lenz, Adarsh Nair, Stefanie Scheu, Pilar M. Domínguez, Agata Karolina Pastorczak, Karin Nebral, , Sanil Bhatia

This study shows HDAC6 inhibition enhances anti-tumoral immune responses and chemosensitivity in myeloid leukemia cells by upregulating RNase T2 and improving chromatin accessibility.

Cell Death and Disease · Mar 7, 2026Peer-reviewedCell Biology

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B

Xiaoli Yang, Pablo Cea‐Medina, Mohanraj Gopalswamy, Aparna Vaidya, Sonja Schavier, Shixin Oltzen, Sofie Moßner, Anfei Huang, Jing Qi, Johanna Maria Hölken, Nicole Elisabeth Teusch, Doreen Manuela Floss, Markus Uhrberg, Holger Gohlke, Stefanie Scheu

This study identifies Beauvericin as an uncompetitive inhibitor of Cathepsin B through NMR, enzyme kinetics, and molecular docking analyses in dendritic cells.

Protein Science · May 24, 2025Peer-reviewedBiochemistry

The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells

Ritu Mann‐Nüttel, Shafaqat Ali, Patrick Petzsch, Karl Köhrer, Judith Alferink, Stefanie Scheu

This study characterizes the transcription factor reservoir and chromatin landscape in naive and TLR9-activated plasmacytoid dendritic cells across multiple timepoints.

BMC Genomic Data · Sep 20, 2021Peer-reviewedMolecular Biology