Author

Ilze Smidt

Harvard UniversityORCID 0009-0008-7850-4635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Bryce OrdwayiD· 1 shared Chenxu GuoiD· 1 shared Eric F. ZaniewskiiD· 1 shared Esther RheinbayiD· 1 shared Garrett Lam· 1 shared Gary X. WangiD· 1 shared Ioannis SanidasiD· 1 shared Kazi Nazrul Islam· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Bryce OrdwayORCID

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1 paper

Recent·Most cited

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

Zuen Ren, Tiziano Bernasocchi, Kiran Kurmi, Chenxu Guo, Kevin Jiang, Eric F. Zaniewski, Garrett Lam, Kazi Nazrul Islam, Shakchhi Joshi, Xin Li, Ilze Smidt, Robert Morris, Bryce Ordway, Veerle Bossuyt, Gary X. Wang, , Leif William Ellisen

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology