Shakchhi Joshi

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

This study identifies a metabolic-epigenetic mechanism linking leucine catabolism to glycolysis that drives resistance to CDK4/6 inhibitors in ER+ breast cancer.

This study provides structural insights into DHODH catalysis and drug resistance by analyzing conformational changes and resistance mutations.

This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

This study identifies and maps glioma-innervating neurons (GINs) using rabies virus tracing and reveals their distinct electrophysiological properties and integration into brain networks.