Author

Ioannis Sanidas

Harvard UniversityORCID 0000-0002-9063-6840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1

Frequent Co-Authors

Michael Charles LanziD· 2 shared Aiden Weaver· 1 shared Benjamin R. TopacioiD· 1 shared Bryce OrdwayiD· 1 shared Cecelia Fleming· 1 shared Chenxu GuoiD· 1 shared Christopher H. BohreriD· 1 shared Daniel R. LarsoniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Michael Charles LanzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division

Benjamin R. Topacio, Cecelia Fleming, Michael Charles Lanz, Mihkel Örd, Mina Memarpoor-Yazdi, Shuyuan Zhang, Shicong Xie, Jürgen Tuvikene, Aiden Weaver, Ioannis Sanidas, Norman Davey, Peter Pryciak, Julien Sage, Seth Rubin, Mardo Kõivomägi, Jan Skotheim

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

bioRxiv · Oct 29, 2026 · PreprintBiochemistry

Cell size-dependent mRNA transcription drives proteome remodeling

Dong Shin You, Christopher H. Bohrer, Purva H. Rumde, Ioannis Sanidas, Matthew P. Swaffer, Daniel R. Larson, Joshua Eric Elias, Michael Charles Lanz, Jan Marcel Skotheim

The paper shows that cell size affects mRNA concentrations, driving proteome changes through transcriptional regulation.

Cell Reports · Jun 1, 2026Peer-reviewedCell Biology

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

Zuen Ren, Tiziano Bernasocchi, Kiran Kurmi, Chenxu Guo, Kevin Jiang, Eric F. Zaniewski, Garrett Lam, Kazi Nazrul Islam, Shakchhi Joshi, Xin Li, Ilze Smidt, Robert Morris, Bryce Ordway, Veerle Bossuyt, Gary X. Wang, , Leif William Ellisen

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology