Chuan Xu

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

The paper creates a regulon atlas mapping TF activity across human cell types and uses it to link disease signatures to cell types and TFs, improving disease risk locus analysis.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

Bin2cell reconstructs cells from high-resolution Visium HD data by integrating morphology and gene expression, improving downstream analysis on mouse brain and human colorectal cancer data.

This study constructs a multiomic atlas of human early skeletal development using single-nuclei transcriptomics, epigenomics, and spatial transcriptomics to uncover regulatory mechanisms and cell states involved in bone and joint formation.

CellHint harmonizes cell types across Human Cell Atlas datasets, revealing new cell states and providing a cross-tissue database with 3.7 million cells.

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

The paper identifies molecular diversity in adult hippocampal and entorhinal cells, revealing cell-type-specific properties related to Alzheimer's disease vulnerability.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.