Author

Melanie Hofmann

Ludwig Boltzmann Institute for Arthritis and RehabilitationORCID 0000-0002-0835-4183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Birgit NiederreiteriD· 2 shared Gernot SchabbaueriD· 2 shared Gerwin HelleriD· 2 shared Anahita Sedighi· 1 shared Axel DietschmanniD· 1 shared Bart EvertsiD· 1 shared David VoehringeriD· 1 shared G.E. SteineriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Birgit NiederreiterORCID

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2 papers

Recent·Most cited

IRF4 is a master regulator of multinucleated giant cell formation

Melanie Hofmann, Gerwin Heller, Markus Kieler, Laszlo Musiejovsky, Lukas Kremp, Martina Kerndl, Paul Ettel, Birgit Niederreiter, Lucia Quemada Garrido, Anahita Sedighi, Thomas Krausgruber, Leonhard X. Heinz, Axel Dietschmann, David Voehringer, Bart Everts, , Gernot Schabbauer

This study identifies IRF4 as a master regulator of multinucleated giant cell formation through integrated single-cell and bulk RNA sequencing, CRISPR/Cas9 editing, and in vivo fate mapping.

bioRxiv · Nov 3, 2025 · PreprintImmunology

MiR-146a controls age related bone loss

Victoria Saferding, Melanie Hofmann, Julia S. Brunner, Birgit Niederreiter, Melanie Timmen, Nathaniel Magilnick, Silvia Hayer, Gerwin Heller, G.E. Steiner, Richard Stange, Mark Boldin, Gernot Schabbauer, Moritz Weigl, Matthias Hackl, Johannes Grillari, , Stephan Blüml

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

bioRxiv · Mar 20, 2020 · PreprintMolecular Biology