Author

Lena Jassowicz

Heidelberg UniversityORCID 0009-0009-1352-6443Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alexander YounsiiD· 1 shared Amir AbdollahiiD· 1 shared Andreas Unterberg· 1 shared Andreas von DeimlingiD· 1 shared Beiping MiaoiD· 1 shared Cansu Eris· 1 shared Catharina LotschiD· 1 shared Cecilia Berzain Battioni· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexander YounsiORCID

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2 papers

Recent·Most cited

ImmunologyImmunityPeer-reviewedJul 1, 2026

P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy

Zhaoqing Hu, Hitoshi Matsuo, Shangce Du…·Chong Sun

This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.

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humanexperimental assay

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Cancer BiologyScience Translational MedicinePeer-reviewedMar 4, 2026

Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat

Gerhard Jungwirth, Junguo Cao, Yimin Pan…·Christel C. Herold‐Mende

This study identifies panobinostat as an effective treatment for aggressive meningiomas through drug screening on tumor organoids and reveals a resistance mechanism involving the HDAC8-TGFβ-EMT axis.

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humanbulk RNA-seq

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