Amir Abdollahi

Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat

This study identifies panobinostat as an effective treatment for aggressive meningiomas through drug screening on tumor organoids and reveals a resistance mechanism involving the HDAC8-TGFβ-EMT axis.

Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo

This study evaluates oxygen-ion FLASH radiation for in vitro and in vivo pancreatic cancer treatment, showing comparable tumor cell killing to standard dose rates.

High LET Particle Therapy Targets Tumor Microtube Networks in Glioblastoma

This study investigates how high LET particle therapy affects tumor microtube networks in glioblastoma, finding that higher LET reduces TM formation and improves cell survival.

Ultra-High Dose Rate Helium Ion Beams: Minimizing Brain Tissue Damage while Preserving Tumor Control

This study compares ultra-high-dose rate helium ion radiotherapy (FLASH) with standard dose rate (SDR) in mice, showing FLASH reduces brain injury and neuroinflammation while maintaining tumor control.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

High complexity cellular barcoding and clonal tracing reveals stochastic and deterministic parameters of radiation resistance

This study uses cellular barcoding to analyze clonal dynamics in response to radiation, finding deterministic and stochastic selection processes contribute to radiation resistance in HNSCC cells.