Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat
Gerhard Jungwirth, Junguo Cao, Yimin Pan, Rolf Warta, Catharina Lotsch, Mahmoud Moustafa, Maximilian Knoll, Tao Yu, Viktor Braun, Lena Jassowicz, Philip Dao Trong, Zhenlin Wang, Alexander Younsi, Moritz Scherer, M. Bendszus, , Christel C. Herold‐Mende
This study identifies panobinostat as an effective treatment for aggressive meningiomas through drug screening on tumor organoids and reveals a resistance mechanism involving the HDAC8-TGFβ-EMT axis.
Science Translational Medicine · Mar 4, 2026Peer-reviewedCancer Biology