Author

Ziyue Kou

Icahn School of Medicine at Mount SinaiORCID 0009-0009-2132-6505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ana Orive-RamosiD· 2 shared Beau BaarsiD· 2 shared Bijaya GaireiD· 2 shared Christos AdamopoulosiD· 2 shared Evripidis GavathiotisiD· 2 shared Mathieu DesaunayiD· 2 shared Poulikos I. PoulikakosiD· 2 shared Stuart A. AaronsoniD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Ana Orive-RamosORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer DiscoveryPeer-reviewedSep 29, 2026

Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition

Ana Orive-Ramos, Bijaya Gaire, Christos Adamopoulos…·Poulikos I. Poulikakos

The paper shows RAF/MEK glues enable full-dose combination with pan-RAF inhibitors, enhancing tumor-selective MAPK inhibition and tumor regression in RAS-mutant models.

DOI 10.1158/2159-8290.cd-25-1596

humanproteomics

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Cancer BiologybioRxivPreprintFeb 14, 2025

RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors

Beau Baars, Ana Orive-Ramos, Ziyue Kou…·Poulikos I. Poulikakos

This study evaluates the signaling inhibition index (SII) of various RAS-targeted inhibitors across RAS-mutant and wild-type models, revealing significant variability in their effectiveness and selectivity.

2 citations

humanstatistical model

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