BiophysicsbioRxivPreprint
Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2
Tatiana Kupriianova, Tessa Schwarzer, Thorben Thalacker…·María García-Alai
This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.
DOI 10.64898/2026.03.30.715250