Author

Daria Kholdina

Brigham and Women's HospitalORCID 0009-0009-4579-8419Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Alexander TyshkovskiyiD· 2 shared Alibek MoldakozhayeviD· 2 shared Bohan ZhangiD· 2 shared Jeremy M. Van RaamsdonkiD· 2 shared Kejun YingiD· 2 shared Vadim N. GladysheviD· 2 shared Adrian MolièreiD· 1 shared Albina Tskhay· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersSystems Biology

Alexander TyshkovskiyORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 30, 2026

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

Alibek Moldakozhayev, Alexander Tyshkovskiy, Pasquale Nigro…·Vadim N. Gladyshev

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

DOI 10.64898/2025.12.28.696721

mousebulk RNA-seq

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Systems BiologybioRxivPreprintJul 4, 2024

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

Alexander Tyshkovskiy, Daria Kholdina, Kejun Ying…·Vadim N. Gladyshev

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

27 citations

mousebulk RNA-seq

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