Bohan Zhang

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

The paper investigates epigenetic aging by comparing single-cell DNA methylation changes across aging and development, revealing stochastic patterns and introducing a new algorithm for analyzing CpG clusters.

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

This study shows that cyclic OKSM expression rejuvenates adult cardiomyocytes in mice with heart failure, improving systolic function without dedifferentiation.

The paper uses epigenetic clocks to show rejuvenation during early mouse and human embryogenesis followed by aging.