Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes
Alibek Moldakozhayev, Alexander Tyshkovskiy, Pasquale Nigro, Zehao Zhang, Albina Tskhay, Cecília Gallottini de Magalhães, Shweta Yadav, Kejun Ying, Alec Eames, Jesse R. Poganik, Shakchhi Joshi, Ji Seul Han, Daria Kholdina, Wayne Mitchell, João A. Paulo, , Vadim N. Gladyshev
This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.
bioRxiv · Sep 30, 2026 · PreprintSystems Biology