Alibek Moldakozhayev

Systemic control and inter-organ communication of ovarian aging

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

Causal Language Detection using Text-Document Features: Methodology and Insights from 10 Years of Gut Microbiome Research

This paper evaluates classifiers for detecting causal language in scientific abstracts and applies the best model to analyze trends in microbiome research from 2015 to 2025.

In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation

This study shows that partial chemical reprogramming in aged mice increases lipid droplet formation, which may cause toxicity and hinder tissue rejuvenation.

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles

The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.

Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.