Functional divergence of the NSs protein defines interferon antagonism and viral fitness across Bhanja virus lineages.
Andrew T. Clarke, Kelsey Davies, Mazigh Fares…·Benjamin Brennan
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MRC University of Glasgow Centre for Virus ResearchORCID 0009-0009-5624-5983Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Andrew T. Clarke, Kelsey Davies, Mazigh Fares…·Benjamin Brennan
Mazigh Fares, Melanie McFarlane, Rhys H. Parry…·Benjamin Brennan
This study shows that SFTSV NSs protein is essential for viral replication in tick cells by suppressing the tick's RNAi response through depletion of virus-derived siRNAs.
Alexandra Wilson, Wael Kamel, Kelsey Davies…·Benjamin Brennan
This study identifies 283 RNA-binding proteins whose activity changes in tick cells infected with Uukuniemi virus, revealing new host-virus interactions and a method to silence gene expression in tick cultures.