This study shows that SFTSV NSs protein is essential for viral replication in tick cells by suppressing the tick's RNAi response through depletion of virus-derived siRNAs.

bioRxiv · Aug 14, 2025 · PreprintMicrobiology

From prototype to outbreak: conserved pathogenesis of Oropouche virus in a novel murine pregnancy model highlights its public health implications

Krista B. Gunter, James M. Bowen, Andrew T. Clarke, Melanie McFarlane, Dorcus C. A. Omoga, Stephanie Pozuelos, Lisa M. Rogers, David Michael Aronoff, Jay Vornhagen, Benjamin Brennan, Natasha L. Tilston‐Lunel

This study establishes a murine model showing Oropouche virus can vertically transmit from mother to fetus, confirming its long-standing ability and public health risks.

bioRxiv · Aug 2, 2025 · PreprintMicrobiology

The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.

Melinda Reuter, Rhys H. Parry, Melanie McFarlane, Rommel J. Gestuveo, Rozeena Arif, Alexander A. Khromykh, Benjamin Brennan, Margus Varjak, Alfredo Castelló, Lars Redecke, Esther Schnettler, Alain Kohl

This study identifies the PAZ domain's role in ensuring accurate 21 nt vsiRNA production by Dcr2 in Aedes aegypti, critical for antiviral responses against Semliki Forest virus.

RNA · Feb 13, 2025Peer-reviewedMicrobiology