Alfredo Castelló

This study investigates whether RPRD2 regulates transcription of HIV-1 and endogenous retroelements, finding no effect on transcription of HIV-1 provirus or endogenous retroelements.

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

This study shows ADAR1 regulates alternative splicing through both RNA editing-dependent and editing-independent mechanisms, with the latter having greater impact.

This study identifies 104 cellular RNA-binding proteins within HIV-1 particles, revealing their role in viral gene expression and infectivity through interactions with HIV-1 genomic RNA.

The paper develops an improved method to capture ribosome-associated proteins and shows viral infections remodel these proteins in a virus-specific manner, with functional implications for viral propagation.

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

This study shows that SFTSV NSs protein is essential for viral replication in tick cells by suppressing the tick's RNAi response through depletion of virus-derived siRNAs.

This study identifies 283 RNA-binding proteins whose activity changes in tick cells infected with Uukuniemi virus, revealing new host-virus interactions and a method to silence gene expression in tick cultures.

This study identifies RNA-binding proteins regulated by type I IFN, revealing a new layer of antiviral response involving post-translational regulation of RNA binding.

The paper identifies protein networks associated with virus-permissive and hostile cellular states through multi-omics analysis, revealing discrepancies between mRNA and protein levels and the role of phosphorylation in infection control.

This study identifies the PAZ domain's role in ensuring accurate 21 nt vsiRNA production by Dcr2 in Aedes aegypti, critical for antiviral responses against Semliki Forest virus.

The paper shows that XRN1-mediated RNA decay provides nucleotides for alphavirus replication by recycling monophosphate nucleotides through the salvage pathway.

This paper introduces BACS, a method for single-base resolution pseudouridine quantification, and identifies {Psi} sites in human RNA and viral transcripts.

The paper describes a 2D chromatography system for proteomics that improves coverage and intensity with nanogram-scale samples, showing benefits for phosphoproteomics and pull-down experiments.

The paper identifies Mub1 as an RNA-binding protein that regulates exosome-dependent mRNA degradation, affecting stress response and gene expression.

This study identifies flg22-responsive RNA-binding proteins in Arabidopsis, revealing their role in plant immunity and uncovering novel immune components.

The paper uses poly(A)+ RNA-protein crosslinking data in fission yeast to analyze RNA-protein complexes and their functional organization.

This study identifies vault RNA1-1 as a riboregulator of autophagy by interacting with p62, showing that it modulates autophagic flux.

The paper investigates how RNA-binding proteins (RBPs) change in response to viral infection and identifies RBPs crucial for viral replication.

This study identifies the PRY/SPRY domain of TRIM25 as its RNA-binding region and shows its role in ubiquitination.