Author

Guanghan Chen

Center for Life SciencesORCID 0009-0009-7286-0759Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Guangshuo OuiD· 3 shared Zhengyang GuoiD· 3 shared Jingyi KeiD· 1 shared Kexin LeiiD· 1 shared Ming Li· 1 shared Shanshan XieiD· 1 shared Shimin WangiD· 1 shared Tianhua Zhou· 1 shared

Activity by Year

2024-2025 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

Guangshuo OuORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 3, 2025

Physiological Reconstitution of Microtubule Doublets

Ming Li, Guanghan Chen, Zhe Chen…·Guangshuo Ou

This study identifies FAP53 as a key factor in B-tubule assembly during microtubule doublet formation and shows its role in ciliogenesis across species.

1 citation

humanC. elegans

𝕏 PostBluesky

Cell BiologybioRxivPreprintOct 7, 2024

Kinesin Autoinhibition Requires Elbow Phosphorylation

Guanghan Chen, Zhengyang Guo, Zhiwen Zhu…·Guangshuo Ou

This study shows that phosphorylation of the elbow region in kinesin OSM-3 regulates its autoinhibition, with phosphorylation mutants affecting cilia entry and motility.

4 citations

C. elegansexperimental assay

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GenomicsG3 Genes Genomes GeneticsPeer-reviewedJun 10, 2024

Transposase-Assisted Tagmentation: An Economical and Scalable Strategy for Single-Worm Whole-Genome Sequencing

Zi Wang, Jingyi Ke, Zhengyang Guo…·Guangshuo Ou

The paper introduces a cost-effective WGS method for model organisms to validate missense variant predictions.

5 citations

C. elegansE. coli

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