Becky S. Leifer

This study identifies small-molecule ligands and inhibitors for 32 cytokines, showing their tractability for small-molecule modulation and providing insights into chemical structures that enable cytokine inhibition.

This study identifies small molecule inhibitors of TOX protein that reverse T cell exhaustion and show cytotoxicity in T-ALL.

The paper benchmarks six MYB inhibitors using a nascent transcriptomics assay, revealing partial specificity, off-target activity, and mixed agonism-antagonism effects.