Angela N. Koehler

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

This study identifies small-molecule ligands and inhibitors for 32 cytokines, showing their tractability for small-molecule modulation and providing insights into chemical structures that enable cytokine inhibition.

The paper maps CDK-drug interactions at single amino acid resolution using genome editing and computational analysis, identifying critical residues and resistance mechanisms.

This study identifies KI-DX-014, a small molecule that binds DDX21 and modulates its RNA-related functions, revealing a new therapeutic approach for targeting DEAD-box proteins.

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

This study identifies small molecule inhibitors of TOX protein that reverse T cell exhaustion and show cytotoxicity in T-ALL.

The paper benchmarks six MYB inhibitors using a nascent transcriptomics assay, revealing partial specificity, off-target activity, and mixed agonism-antagonism effects.