Author

Elizabeth J. Giacobe

University of PittsburghORCID 0009-0009-8506-011XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Gideon H. HillebrandiD· 3 shared Sophia M. CarliniD· 3 shared Thomas Alexander HooveniD· 3 shared A Peters· 1 shared Austin S NeeliD· 1 shared C Nichols· 1 shared David Michael AronoffiD· 1 shared Felicia D KempiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

Gideon H. HillebrandORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 16, 2026

The bacterial cell membrane acts as a dynamic heme reservoir during group B Streptococcus bloodstream infection

Gideon H. Hillebrand, Heather A Stephenson, Elizabeth J. Giacobe…·Thomas Alexander Hooven

DOI 10.64898/2026.05.15.725516

humanexperimental assay

𝕏 PostBluesky

MicrobiologyMolecular MicrobiologyPeer-reviewedSep 13, 2025

A Cas12a Toolbox for Rapid and Flexible Group B Streptococcus Genomic Editing and CRISPRi

Gideon H. Hillebrand, Sophia M. Carlin, Elizabeth J. Giacobe…·Thomas Alexander Hooven

This paper develops a Cas12a-based toolkit for efficient genomic editing and CRISPRi in Group B Streptococcus, enabling targeted gene modifications and inducible gene silencing with minimal off-target effects.

5 citations

experimental assaygenetic perturbation / CRISPR

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MicrobiologyInfection and ImmunityPeer-reviewedMar 21, 2025

A CRISPRi Library Screen in Group B Streptococcus Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions

Kyle Firestone, Kathyayini P. Gopalakrishna, Lisa M. Rogers…·Thomas Alexander Hooven

This study uses CRISPRi to identify Sip as a key surface protein in GBS that modulates host interactions and pathogenesis.

1 citation

virusgenetic perturbation / CRISPR

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