Author

Jiajun He

Chinese Academy of SciencesORCID 0009-0009-8845-9150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Fangfang Yao· 3 shared Hongping WeiiD· 3 shared Yuhong LiiD· 2 shared F Chen· 1 shared Fangyuan Chen· 1 shared Fen Hu· 1 shared Hang Yang· 1 shared Hang YangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Fangfang Yao

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 29, 2026

Engineering Dual-Target Chimeric Lysins for Synergistic Eradication of Porphyromonas gingivalis

Fangfang Yao, Jiajun He, Fangyuan Chen…·Yuhong Li

This study engineers dual-target chimeric lysins to eradicate Porphyromonas gingivalis in periodontitis, showing significant bactericidal activity and reduced inflammation in a mouse model.

DOI 10.64898/2026.04.27.720852

mouseexperimental assay

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MicrobiologybioRxivPreprintApr 13, 2026

Structure-based similarity network accelerates the discovery of lysins as oral microbiome modulators targeting periodontal pathogens

Fangfang Yao, Jiajun He, Raphael Nyaruaba…·Yuhong Li

The paper identifies potent periodontal lysins using a structure-based pipeline and shows LysPd078 effectively modulates oral microbiome communities in preclinical models.

2 citations

mouseprotein structure

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BiochemistryeLifePeer-reviewedNov 26, 2024

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

Li Zhang, Fen Hu, Zirong Zhao…·Hang Yang

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

3 citations

bacteria (other)protein structure

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