Hongping Wei

Engineering Dual-Target Chimeric Lysins for Synergistic Eradication of Porphyromonas gingivalis

This study engineers dual-target chimeric lysins to eradicate Porphyromonas gingivalis in periodontitis, showing significant bactericidal activity and reduced inflammation in a mouse model.

Structure-based similarity network accelerates the discovery of lysins as oral microbiome modulators targeting periodontal pathogens

The paper identifies potent periodontal lysins using a structure-based pipeline and shows LysPd078 effectively modulates oral microbiome communities in preclinical models.

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

Rapid phylogenetic analysis of African swine fever virus from metagenomic sequences

This paper presents a method to rapidly analyze ASFV phylogenetics from metagenomic sequences without virus isolation, identifying two major clades and linking Wuhan isolates to earlier outbreaks.