Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation
O. O. Krasnovskaya, D. Abramchuk, A. Vaneev, P. Gorelkin, M. Abakumov, R. Timoshenko, N. Chmelyuk, V. Vadehina, R. Kuanaeva, E. V. Dubrovin, V. Kolmogorov, E. K. Beloglazkina, A. S. Erofeev
Abstract
Alz-5 acts as a bifunctional chelator that can interact with various A{beta} aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in A{beta}42 - affected SH-SY5Y cell. AFM data obtained on A{beta}42 fibrils clearly indicate an anti-aggregating property of Alz-5. Youngs modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in A{beta}42 - affected SH-SY5Y cells.
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