Small Molecule Induced Toxic Human-IAPP Species Characterized by NMR
S. Cox, D. Rodriguez Camargo, Y.-H. Lee, M. I. Ivanova, V. Padmini, B. Reif, A. Ramamoorthy
Abstract
In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective which is reflected in a strong interference with hIAPP aggregation, while showing weaker interactions with human-calcitonin and Amyloid-{beta}1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.
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