Thenmalarchelvi Rathinavelan

The paper mathematically devises 156 unique quadruplex motifs and develops a tool to model their energy-minimized structures, revealing greater structural complexity than previously known.

This paper investigates how Ac-BIM-acid affects amyloid fibril morphology of Stm1_N1-113 and Aβ42 using AFM and NMR, showing structural modulation at different concentrations.

MDTAP automates the analysis of permeation events across membrane proteins and nucleic acids from MD trajectories, providing visualization and insights into solute/solvent transport mechanisms.

The paper analyzes 392 experimentally determined DNA quadruplex structures to identify 48 unique motifs, which can be classified into continuous and discontinuous types, aiding in quadruplex engineering and drug design.

NuCDB is a database of nucleic acid circular dichroism spectra that facilitates the study of secondary structures and supports machine learning model training for structure prediction.

The paper introduces a new antibody capture method to accurately capture G4 structures in human cells and shows that G4 formation is constrained by sequence properties and nuclear environment.

The paper analyzes global SARS-CoV-2 proteome variation to identify mutational hotspots in drug and vaccine targets, finding that some mutations are co-occurring and others are geographically prevalent.

The paper introduces K-PAM, a platform for serotyping Klebsiella species, modeling antigen structures, and identifying hypervirulent strains using computational methods and gene/protein markers.

The paper uses an extreme gradient boosting decision-tree algorithm to predict nucleic acid secondary structures from circular dichroism spectra with high accuracy.

STRIDER estimates steric hindrance and coordination numbers for biomolecules using Cartesian coordinates, aiding in structural analysis and virtual screening.