Physics and Imaging in Radiation OncologyCancer BiologyPeer-reviewed journal article
Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo
Celine KarleiD, Domenico Ivan Filosa, Mahdi AkbarpouriD, Nora Schuhmacher, Stephan BronsiD, R. Cee, Christian SchömersiD, Stefan Scheloske, Kristoffer PeterssoniD, Thomas Haberer, Amir AbdollahiiD, Jürgen DebusiD, Thomas TessonnieriD, Mahmoud MoustafaiD, Andrea MairaniiD, Ivana ĐokićiD
Abstract
This study showcases the feasibility of oxygen ion ultra-high dose rate irradiation for in vitro and in vivo experiments at the Heidelberg Ion-Beam Therapy Center. The results indicate comparable effectiveness to standard dose rate in pancreatic cancer cell killing and tumor control, highlighting its potential to address challenges in treating radio-resistant tumors.
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