Jürgen Debus

The paper introduces Suco and Compocyte to classify immune cells from 3,965 patients, identifying new macrophage and monocyte states and T cell memory erosion in metastases.

This study identifies panobinostat as an effective treatment for aggressive meningiomas through drug screening on tumor organoids and reveals a resistance mechanism involving the HDAC8-TGFβ-EMT axis.

This study evaluates oxygen-ion FLASH radiation for in vitro and in vivo pancreatic cancer treatment, showing comparable tumor cell killing to standard dose rates.

This study investigates how high LET particle therapy affects tumor microtube networks in glioblastoma, finding that higher LET reduces TM formation and improves cell survival.

This study compares ultra-high-dose rate helium ion radiotherapy (FLASH) with standard dose rate (SDR) in mice, showing FLASH reduces brain injury and neuroinflammation while maintaining tumor control.

This study uses cellular barcoding to analyze clonal dynamics in response to radiation, finding deterministic and stochastic selection processes contribute to radiation resistance in HNSCC cells.