Nature Structural & Molecular BiologyMolecular BiologyPeer-reviewed journal article
Structural basis for Fc receptor recognition of immunoglobulin M
Qu CheniD, Rajesh P. Menon, Laura MasinoiD, Pavel TolariD, Peter B. RosenthaliD
Abstract
FcR is the IgM-specific Fc receptor involved in the survival and activation of B cells. Using cryo-EM, we reveal eight binding sites for the human FcR Ig domain on the IgM pentamer, one of which overlaps with the receptor binding site for the transcytosis receptor pIgR, but a different mode of binding explains Ig isotype specificity. The complex explains engagement with polymeric serum IgM and the monomeric IgM B cell receptor.
- organism: human
- assay: protein structure
- research focus: protein structure prediction
- approach: experimental assay
- Citations
- 26
- FWCI
- 4.29
- Field percentile
- top 5%
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