Pavel Tolar

The paper shows that human IgE+ plasma cells are selectively killed by BCR crosslinking due to a JNK/PTEN/BIM signaling axis, distinct from mouse mechanisms, and highlights therapeutic implications for anti-IgE antibodies.

This study identifies CCR2 as a key regulator of IgE-producing plasma cell migration by comparing their chemokine receptor profiles and migration behavior to IgG1+ cells.

This study shows that fusing C3d to HIV-1 Env immunogens enhances germinal center responses and improves vaccine immunogenicity.

This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.

This study uses cryo-EM to determine the structural basis of Fc receptor recognition of immunoglobulin M, identifying binding sites and explaining isotype specificity.