hsa-miR-130b-3p Predicts Poor Prognosis Across Renal Cell Carcinoma Subtypes via CD8+T Cell Depletion: A Multi-Omics and Clinical Validation StudyImmune Evasion
Abstract
Abstract BackgroundRenal cell carcinoma (RCC) is an aggressive genitourinary malignancy comprising three major subtypes: clear cell (KIRC), chromophobe (KICH), and papillary (KIRP). MicroRNAs (miRNAs) orchestrate renal cell carcinoma (RCC) progression, yet pan-subtype biomarkers remain elusive. MethodsHsa-miR-130b-3p was upregulated in all subtypes (log2FC=1.65,FDR=1.07x10- in GSE16441), correlating with poor OS (HR=1.56-2.38, p View larger version (36K): org.highwire.dtl.DTLVardef@18e8forg.highwire.dtl.DTLVardef@3668f5org.highwire.dtl.DTLVardef@24d6fdorg.highwire.dtl.DTLVardef@9eb696_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOFigure 1C_FLOATNO Graphical Abstract C_FIG
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