Author

T. Straub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 3 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 5 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Assay:proteomics· 3 Assay:ATAC-seq· 2

Frequent Co-Authors

T. Brocker· 4 shared A. B. Krug· 2 shared A. Imhof· 2 shared E. Winheim· 2 shared J. Hellmuth· 2 shared J. Kranich· 2 shared K. Lutz· 2 shared K. Stark· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

T. Brocker

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

C. Kurat, P. Bansal, S. Lahiri, C. Kumar, L. Galanti, E. Chacin, M. A. Ortiz-Bazan, M. Mueller, P. Vizjak, T. Straub, F. Mueller-Planitz, A. Aguilera, B. Gomez-Gonzalez, B. Pfander, A. Imhof

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

bioRxiv · Jun 10, 2024 · PreprintBiochemistry

Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency

A. Chanou, M. Weiss, K. Holler, T. Straub, J. Krietsch, A. Sanchi, H. Ummethum, C. S. K. Lee, E. Kruse, M. Trauner, M. Werner, M. Lalonde, M. Lopes, A. Scialdone, S. Hamperl

The paper develops MATAC-Seq to analyze single-molecule chromatin accessibility at replication origins, identifying chromatin features that predict origin efficiency in yeast.

bioRxiv · Mar 14, 2023Biochemistry

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

F. Gaertner, H. Ishikawa-Ankerhold, S. Stutte, W. Fu, C. Guo, J. Weitz, A. Dueck, Z. Zhang, D. van den Heuvel, V. Fumagalli, M. Lorenz, L. von Baumgarten, K. Stark, T. Straub, S. von Stillfried, , S. Massberg

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

bioRxiv · May 31, 2022 · PreprintImmunology

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

L. Rausch, K. Lutz, M. Schifferer, E. Winheim, R. Gruber, L. Rinke, J. Hellmuth, C. Scheerer, M. Muenchhoff, C. Mandel, M. Bergwelt-Baildon, M. Simons, T. Straub, A. B. Krug, J. Kranich, T. Brocker

The paper identifies PS+ PMPs as a marker for disease severity in COVID-19 by showing their correlation with immune dysfunction and clinical outcomes.

bioRxiv · Jun 18, 2021Immunology

Impaired function and delayed regeneration of dendritic cells in COVID-19

E. Winheim, L. Rinke, K. Lutz, A. Reischer, A. Leutbecher, L. Wolfram, L. Rausch, J. Kranich, P. R. Wratil, J. Huber, D. Baumjohann, S. Rothenfusser, J. Hellmuth, C. Scherer, M. Muenchhoff, , A. B. Krug

This study examines dendritic cell and monocyte function and regeneration in COVID-19 patients, finding persistent reductions and functional impairments linked to disease severity.

bioRxiv · May 26, 2021 · PreprintImmunology

Abscisic-acid-dependent regulation of Arabidopsis thaliana ammonium transport relies on ABI1 control of CIPK23 and AMT1

P. Ganz, R. Porras-Murillo, T. Ijato, J. Menz, T. Straub, N. Stuehrwohldt, N. Moradtalab, U. Ludewig, B. Neuhaeuser

The paper identifies ABI1 as an activator of ammonium transporters in Arabidopsis thaliana, showing it regulates AMT1 phosphorylation through CIPK23 in response to abscisic acid.

bioRxiv · Feb 9, 2021 · PreprintPlant Biology

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

E. Oberbeckmann, N. Krietenstein, V. Niebauer, Y. Wang, K. Schall, M. Moldt, T. Straub, R. Rohs, K.-P. Hopfner, P. Korber, S. Eustermann

This study identifies DNA shape/mechanics as key determinants for nucleosome positioning by the INO80 chromatin remodeler in yeast.

bioRxiv · Nov 3, 2020Biochemistry

Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis

V. Friedrich, I. Forne, D. Matzek, D. Ring, B. Popper, L. Jochum, S. Spriewald, T. Straub, A. Imhof, A. Krug, B. Stecher, T. Brocker

This study identifies Helicobacter hepaticus as a disease driver in a CD40-mediated colitis model by showing its role in inducing inflammatory immune responses through specific antigen recognition.

bioRxiv · Apr 21, 2020 · PreprintImmunology

A mosaic renal myeloid subtype with T-cell inhibitory and protumoral features is linked to immune escape and survival in clear cell renal cell cancer

D. Brech, T. Straub, E. Kokolakis, M. Irmler, J. Beckers, F. Buettner, E. Schaeffeler, S. Winter, M. Schwab, P. J. Nelson, E. Noessner

The paper identifies a renal myeloid subtype in clear cell renal cell cancer that exhibits immunoinhibitory and tumor-promoting features, correlates with poor patient survival, and suggests therapeutic targets.

bioRxiv · Jan 20, 2020 · PreprintImmunology

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation

A. Buschle, P. Mrozek-Gorska, S. Krebs, H. Blum, F. M. Cernilogar, G. Schotta, D. Pich, T. Straub, W. Hammerschmidt

This study shows that EBV lytic reactivation causes global chromatin remodeling and transcriptome disruption in host cells before viral DNA replication.

bioRxiv · Mar 20, 2019Cell Biology