MicroRNA in disease regulation

mRNA deep sequencing profiling and integrative miRNA-mRNA network analysis in pediatric Burkitt leukemia and lymphoma

This study profiles mRNA and miRNA expression in pediatric Burkitt leukemia and lymphoma, identifying dysregulated miRNA-mRNA networks and key pathways involved in proliferation and immune signaling.

Development of gemcitabine-modified miR-15a as a novel, multimodal treatment strategy to overcome 5-FU and oxaliplatin resistance in colorectal cancer

This paper develops Gem-miR-15a, a gemcitabine-modified microRNA, which overcomes 5-FU and oxaliplatin resistance in colorectal cancer with high potency and low toxicity.

MiR-208b-3p is an upstream regulator of redox-associated cardiomyocyte survival

This study identifies miR-208b-3p as a regulator linking cardiac stress adaptation with redox and survival responses through its effects on Myh7 and ATM.

A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer

The paper maps regulatory connections between RBPs and miRNAs in cancer, showing RBP-driven regulation contributes to miRNA activity heterogeneity and identifies DDX55 as a key regulator of miR-29-3p.

Coordinated microRNA-mRNA regulatory remodelling across the compressed maturation of the African killifish (Nothobranchius furzeri)

The paper integrates miRNA and mRNA expression across developmental stages in African killifish to identify coordinated regulatory changes during rapid maturation.

Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer

The paper identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer through integrative bioinformatics and experimental validation.

Translation of a small upstream open reading frame functions as a rheostat for the regulation of lin-41 by the Let-7 microRNA in Caenorhabditis elegans

The paper identifies a uORF in the lin-41 5'UTR that modulates Let-7 microRNA regulation of lin-41 translation in C. elegans.

LSD-pipeline: Causal Inference of miRNA Network Effects in Alzheimer's Disease

The paper develops the LSD pipeline to infer causal miRNA network effects in Alzheimer's disease, identifying four miRNAs as biomarkers with >86% ROC accuracy.

Transcriptomic profiling reveals estradiol and progesterone specific microRNA signatures differentially regulate mRNA targets in vaginal epithelial cells

The paper identifies hormone-specific microRNA signatures in vaginal epithelial cells and their effects on mRNA targets related to cell adhesion, immune response, and pathogen susceptibility.

The miR-615-5p/ID1 Axis Regulates Autophagy-Associated Migration in Pancreatic Ductal Adenocarcinoma

This study identifies miR-615-5p as a tumor-suppressive miRNA that regulates ID1 expression and autophagy-associated migration in PDAC.

miRNA-mediated regulation of lineage plasticity in YY1 knockout pro-B cells

This study identifies YY1-dependent miRNA networks that regulate B cell identity and lineage commitment through transcriptional and post-transcriptional mechanisms in pro-B cells.

miRAssist: a context-aware, evidence integration framework for interpretable miRNA-target prioritization

miRAssist integrates six evidence types to prioritize miRNA-target interactions, outperforming existing models and providing interpretable results.

A pan-cancer analysis of microRNA tissue specificity and its association with dysregulation

The paper analyzes miRNA tissue specificity in normal and tumor tissues, identifies dysregulated miRNAs, and links them to oncogenic pathways.

Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis

This study shows that obesity increases atherosclerosis through an inter-tissue miR-30e-SLC7A11 axis, where adipose-derived miR-30e-5p targets SLC7A11 in vascular endothelial cells, leading to metabolic and functional impairments.

Social isolation is associated with microRNA expression changes in the visual system of poison frog tadpoles

The paper shows that social isolation in poison frog tadpoles alters miRNA expression in the midbrain and eyes, linked to behavioral changes and potential neuroplasticity mechanisms.

A deep generative decoder predicts microRNA expression from bulk and single-cell mRNA profiles

miDGD predicts microRNA expression from bulk and single-cell mRNA profiles using a deep generative decoder, achieving high accuracy across diverse datasets and cell types.

GIN-CRC-Pareto: A graph-based Pareto-optimal multi-task learning framework to identify miRNA-target interactions in colorectal cancer

GIN-CRC-Pareto identifies miRNA-target interactions in colorectal cancer using a graph-based multi-task learning framework, outperforming existing methods in accuracy and AUC.

Investigating dietary microRNA stability and function using a transgenic milk model with unique microRNA sequences

This paper uses a transgenic cow model to study the stability and function of unique microRNA sequences in milk extracellular vesicles, showing differential digestion resistance and in vitro gene regulatory effects.

Generation of miR-141/200c conditional knockout mice from knockout-first, reporter-tagged parent and functional validation of the floxed allele

The paper validates a two-step breeding protocol for generating miR-141/200c conditional knockout mice and shows the importance of removing the lacZ/Neo cassette for normal gene expression.

Pan-cancer analysis identifies nine conserved miRNA regulators of tumor cytolytic activity and clinically actionable immune targets

This study identifies nine conserved miRNAs regulating tumor cytolytic activity across cancers and highlights clinically actionable immune targets.

Overexpression of miR-424(322)/-503 induces severe dilated cardiomyopathy by regulating the fatty acid oxidation gene expression program

This study shows that overexpression of miR-424(322)/-503 in the heart causes severe dilated cardiomyopathy by disrupting fatty acid oxidation and metabolic function.

DJ-1/PARK7 Determines miRNA Network Plasticity During Genotoxic Stress

This study shows DJ-1/PARK7 influences miRNA network plasticity during genotoxic stress by altering miRNA abundance and regulatory machinery.

African Green Monkey Cerebrospinal Fluid miRNome Captures Conserved miRNAs Relevant to Human Neurodegenerative Disease

The paper characterizes the miRNome of African green monkey cerebrospinal fluid, identifying conserved miRNAs relevant to human neurodegenerative diseases and highlighting species-specific variations.

MicroRNA correlates of resilience to Alzheimer's disease identify candidate therapeutic targets for neuroprotection

This study identifies miRNA signatures associated with resilience to Alzheimer's disease, revealing potential therapeutic targets for neuroprotection.

miRNA-mRNA Interaction Network Analysis in Alzheimer's Disease for Biomarker Discovery

The paper identifies AD-associated miRNA-mRNA regulatory signatures and potential biomarkers using transcriptomic data from ADNI and GSE48552.

Direct interaction between miR-210-5p and HIF-1α regulates HIF-dependent transcription

The paper identifies miR-210-5p as a nuclear hypoxamiR that directly binds HIF-1 and enhances HIF-dependent transcription, revealing a new RNA-mediated regulatory mechanism.

Upregulation of distinct miRNAs in SARS-CoV-2 infected individuals: A differential signature of circulating miRNAs

This study identifies seven miRNAs upregulated in SARS-CoV-2 infected individuals, with some showing strong diagnostic accuracy, and links them to immune-related genes.

Human brain microRNAs exhibit cell-type specificity and agedependence

The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.

miR-100-5p modulates postprandial triglyceride response by targeting PCSK9

This study identifies miR-100-5p as a regulator of postprandial triglyceride response by targeting PCSK9, suggesting its potential as a biomarker for cardiovascular risk.

Altered salivary miRNA profiles and microbiome composition correlate with psychosocial stress

The paper identifies dysregulated miRNAs and microbial pathway changes in saliva linked to psychosocial stress in police officers.