bioRxivBioinformaticsPreprint
Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection
Hemant SuryawanshiiD, Pavel S MorozoviD, Thangamani MuthukumariD, Benjamin Robert tenOeveriD, Masashi YamajiiD, Zev WilliamsiD, Thomas TuschliD
Abstract
We have analyzed the cell-type-specific expression of the renin-angiotensin system (RAS) components across 141 cell types or subtypes as defined by single-cell RNA-seq (scRNA-seq) analysis. ACE2, one of the components of RAS, also facilitates SARS-CoV-2 entry into cells in cooperation with its associated protease TMPRSS2. Therefore, our analysis also contributes to the understanding of SARS-CoV-2 infection, spreading of the virus throughout the body, and potential viral interference with RAS in COVID-19 patients.
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