Thomas Tuschl

Rethinking the Benign Nature of Class II Lupus Nephritis

This study defines the single-cell landscape of Class II lupus nephritis and identifies fibroblast transcriptional programs and chronicity index as potential predictors of kidney outcomes.

Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts

This study uses scRNA-seq to analyze kidney allograft biopsies and identifies recipient-derived fibroblasts and other cell states associated with fibrosis and rejection.

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

RTEL1 Influences the Abundance and Localization of TERRA RNA

This study shows that RTEL1 helicase regulates TERRA RNA abundance and localization, with implications for telomere stability and disease.

Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection

The paper examines cell-type-specific expression of RAS components across 141 cell types using scRNA-seq and links ACE2 expression to SARS-CoV-2 infection mechanisms.

Detection of circulating extracellular mRNAs by modified small RNA-sequencing analysis

This study improves detection of extracellular mRNAs using modified small RNA-sequencing, revealing their potential as biomarkers and showing increased resolution in disease states.

Deciphering human ribonucleoprotein regulatory networks

The paper analyzes RBP-RNA interactions across 64 RBPs to identify regulatory modules and their functional roles in RNA metabolism and localization.