bioRxivBiophysicsPreprint
Investigation of the Effects of N-Linked Glycans on the Stability of the Spike Protein in SARS-CoV-2 by Molecular Dynamics Simulations
Abstract
We perform all-atom molecular dynamics simulations to study the effects of the N-linked glycans on the stability of the spike glycoprotein in SARS-CoV-2. After a 100 ns of simulation on the spike proteins without and with the N-linked glycans, we found that the presence of glycans increases the local stability in their vicinity; even though their effect on the full structure is negligible. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=95 SRC="FIGDIR/small/475397v1_ufig1.gif" ALT="Figure 1"> View larger version (32K): org.highwire.dtl.DTLVardef@cb1c1dorg.highwire.dtl.DTLVardef@a2ecbeorg.highwire.dtl.DTLVardef@64db68org.highwire.dtl.DTLVardef@180a1aa_HPS_FORMAT_FIGEXP M_FIG C_FIG
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