Author

B. S. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

R. Faller· 3 shared S. Nandi· 3 shared Y. Huang· 3 shared K. A. McDonald· 2 shared S. A. Minami· 2 shared S. Jung· 2 shared A. Bernardi· 1 shared K. McDonald· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

R. Faller

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Production of novel Spike truncations in Chinese hamster ovary cells

S. A. Minami, S. Jung, Y. Huang, B. S. Harris, M. W. Kenaston, R. Faller, S. Nandi, K. A. McDonald, P. S. Shah

The paper improves Spike protein expression in CHO cells by developing truncations that outperform full-length Spike and RBD in expression levels and antibody binding.

bioRxiv · Dec 6, 2021 · PreprintBioengineering

SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction

Y. Huang, B. S. Harris, S. A. Minami, S. Jung, P. Shah, S. Nandi, K. McDonald, R. Faller

The paper uses molecular dynamics simulations to show that glycosylation enhances the binding strength and range of SARS-CoV-2 Spike to ACE2 through glycan-mediated interactions.

bioRxiv · Jul 15, 2021Biophysics

Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain

A. Bernardi, Y. Huang, B. S. Harris, Y. Xiong, S. Nandi, K. A. McDonald, R. Faller

The paper develops and simulates fully glycosylated ACE2-Fc fusion proteins and their interaction with SARS-CoV-2 spike protein RBD, showing glycan effects on conformation and optimizing glycosylation modeling algorithms.

PLOS ONE · Aug 5, 2020Peer-reviewedBiophysics