bioRxivNeurosciencePreprint
Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
Çiğdem Gelegen, Diana CashiD, Katarina IlićiD, Millie Sander, Eugene KimiD, Camilla SimmonsiD, Michel Bernanos, Joana LamaiD, Karen RandalliD, Jon T. BrowniD, Svjetlana Kalanj BognariD, Samuel F. CookeiD, К. Ray ChaudhuriiD, Clive G. BallardiD, Paul T. FrancisiD, Ivana RosenzweigiD
Abstract
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of -synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.
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