A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of Fmr1 KO mice and caused by loss of FMRP in cortical excitatory neurons
Sara S. Kornfeld-Sylla, Çiğdem Gelegen, Jordan E. Norris, Francesca A. Chaloner, Maia Lee, Michael Khela, Maxwell J. Heinrich, Peter S.B. Finnie, Lauren E. Ethridge, Craig A. Erickson, Lauren Schmitt, Samuel F. Cooke, Carol L. Wilkinson, Mark F. Bear
The paper identifies a shared electrophysiological biomarker of Fragile X Syndrome in human and mouse models, showing slowed alpha oscillations linked to FMRP loss in excitatory neurons.
bioRxiv · Mar 19, 2025 · PreprintNeuroscience