Clive G. Ballard

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This study identifies parieto-temporo-occipital cortical volume loss in Parkinson's Disease psychosis and links it to serotonergic receptor gene expression.

This study shows fasudil reverses gene expression patterns associated with neurodegenerative disease in Alzheimer's model mice.

This paper demonstrates that multi-parametric manganese-enhanced MRI (MEMRI) can detect senile plaques in rodent AD models, showing manganese binds to plaques in 5xFAD mice but not TgF344-AD rats.

The paper shows REM and NREM sleep abnormalities and structural changes in GBA1 mice, linking them to RBD and alpha-synucleinopathy progression.

The paper identifies cardiovascular and infectious disease mechanisms linked to atypical antipsychotic side-effects using transcriptome analysis and bioinformatics.

This study finds a genetic link between schizophrenia polygenic risk and psychotic symptoms, particularly delusions, in Alzheimer's disease through a meta-analysis of 11 cohort studies.

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.