bioRxivMicrobiology
Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses
N. Mishra, X. Huang, S. Joshi, C. Guo, J. Ng, R. Thakkar, Y. Wu, X. Dong, Q. Li, R. Pinapati, E. Sullivan, A. Caciula, R. Tokarz, T. Briese, J. Lu, W. I. Lipkin
Abstract
Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity to the human coronaviruses (HCoV) SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report the identification of humoral immune responses to SARS-CoV-2 and other HCoV peptides that can be used to detect asymptomatic, mild and, severe SARS-CoV-2 infections, and may enable the discovery of biomarkers for immunity following infection or vaccination.
- organism: human
- assay: proteomics
- research focus: host-pathogen & immune response
- approach: experimental assay
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